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Sido B, Hack V, Hochlehnert A et al. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut. 1998;42:485-492.

Pinto M, Soares-Mota S, Lopes M et al. Does active Crohn’s disease have decreased intestinal antioxidant capacity? J Crohns Colitis 2013;7:e358-e366.

Esworthy R, Binder S, Doroshow J et al. Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol Chem. 2003;384:597-607.

Nagy D, Fülesdi B, Hallay J.  Role of selenium in gastrointestinal inflammatory diseases. Orv Hetil 2013;154:1636-1640.

Brigelius-Flohé R, Kipp A. Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis. Ann N Y Acad Sci. 2012;1259:19-25.

Li N, Neu J. Glutamine deprivation alters intestinal tight junctions via a PI3K/Akt mediated pathway in Caco-2 cells. J Nutr 2009;139:710-714.

Lecleire S, Hassan A, Marion-Letellier R et al. Combined glutamine and arginine decrease proinflammatory cytokine production by biopsies from Crohn’s patients in association with changes in nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways. J Nutr 2008;138:2481-2486.

Li J, Langkamp-Henken B, Suzuki K et al Glutamine prevents parenteral nutrition-induced increases in intestinal permeability. J Parent Enteral Nutr 1994;18:303-307.

Ranaldi G, Ferruzza S, Canali R et al. Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα. J Nutr Biochem 2013;24:967-976.

El Tawil A. Zinc supplementation tightens leaky gut in Crohn’s disease. Inflamm  Bowel Dis 2012;18:E399.

Zhong W, McClain C, Cave M et al. The role of zinc deficiency in alchohol-induced intestinal barrier dysfunction. Am J Physiol Gastrointest Liver Physiol 2010;298:G625-633.

Long K, Santos J et al. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children. J Nutr 2006;136:2600-2605.

Bai A, Lu N, Guo Y et al. All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis. J Leukoc Biol. 2009;86:959–969.

Aghkassi E, Wendland B, Steinhart H et al. Antioxidant vitamin supplementation in Crohn’s disease decreases oxidative stress: a randomized controlled trial. Am J Gastroenterol 2003;98:348-353.

Cevikel MH, Tuncyurek P, Ceylan F et al. Supplementation with high-dose ascorbic acid improves intestinal anastomotic healing. Eur Surg Res. 2008;40:29-33.

Palmer M, Weaver C. Linking vitamin D deficiency to inflammatory bowel disease. Inflamm Bowel Dis 2013;19:2245-2256.

Ulitsky A, Ananthakrishnan AN, Naik A et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. J Parenter Enteral Nutr. 2011 May;35:308-316.

BlanckS.Vitamin D deficiency is associated with ulcerative colitis disease activity.Dig Dis Sci.2013;58:1698-1702.

Nakajima S, Iijima H, Egawa S et al. Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nutrition. 2011 Oct;27:1023-1028.

Schoon E, Muller M Vermeer C et al. Low serum and bone vitamin K status in patients with longstanding Crohn’s disease: another pathogenic factor of osteoporosis in Crohn’s disease? Gut 2001;48:473-477.

Gumurdulu Y, Serin E, Ozer B et al. The impact of B12 treatment on gastric emptying time in patients with Helicobacter pylori infections. J Clin Gastroenterol 2003;37:230-233.

Oh S. Proton pump inhibitors – uncommon adverse effects. Aust Fam Physician 2011;40:705-708.

Sonne S, Shekhawat PS, Matern D et al. Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response. PLoS One. 2012;7:e47729.

Mikhailova T,Sishkova E, Poniewierka E et al. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. Aliment Pharmacol 2011;34:1088-1097.

Shekhawat P, Srinivas S, Matern D et al. Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice. Mol Genet Meta. 2007;92:315-324.

Larsson S, Orsini N, Wolk A. Vitamin B6 and Risk of Colorectal Cancer: A Meta-analysis of Prospective Studies. JAMA 2010;303:1077-1083.

Lee J, Li H, Giocannucci E et al. Prospective study of plasma vitamin B6 and risk of colorectal cancer in men. Cancer Epidemiol Biomarkers Prev 2009;18:1197-1202.

Crott J, Liu Z et al. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines.J Nutr Biochem 2008;19:328-335.

Knock E, Deng L, Wu Q et al.  Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c. Cancer Res 2006;66:10359-10356.

Mourelle M, Guarner F, Malagelada J. Polyunsaturated phosphatidylcholine prevents stricture formation in a rat model of colitis. Gastroenterolgy 1996;110:1093-1097.

Dunjic B, Axelson J. Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats. Scand J Gastroenterol 1993;28:89-94.

Pachikian BD, Neyrinck AM, Deldicque L et al. Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice. J Nutr. 2010;140:509-514.

Mackay J, Bladon P. Hypomagnesaemia due to proton-pump inhibitor therapy: a clinical case series.QJM. 2010;103:387-395.

Henrotte J, Aymard N, Allix M et al. Effect of pyridoxine and magnesium on stress-induced gastric ulcers in mice selected for low or high blood magnesium levels. Ann Nutr Metab 1995;39:285-290.

Trivedi P, Jena G.Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: Studies on inflammation, oxidative stress, DNA damage and fibrosis. Food Chem Toxicol. 2013;59:339-55.

Kolgazi M, Jahovic N, Yüksel M et al. Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats. J Gastroenterol Hepatol. 2007;22:1859-1865.